[1]张静,李应东,高丽.辛芷鼻敏胶囊对变应性鼻炎大鼠脾脏组织中[J].甘肃中医药大学学报,2006,(03):17-19.
 Zhang Jing,Li Yingdong,Gao Li.Effects of Xinzhi Bimin Capsules on the contents of IL-5 in the spleen and the expression of EOS in the nasal mucosa of rats with allergil rhinitis[J].Journal of Gansu University of Chinese Medicine,2006,(03):17-19.
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辛芷鼻敏胶囊对变应性鼻炎大鼠脾脏组织中()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
期数:
2006年03期
页码:
17-19
栏目:
实验研究
出版日期:
1900-01-01

文章信息/Info

Title:
Effects of Xinzhi Bimin Capsules on the contents of IL-5 in the spleen and the expression of EOS in the nasal mucosa of rats with allergil rhinitis
作者:
张静12 李应东1 高丽3
1. 甘肃中医学院, 甘肃 兰州 730000;
2. 兰州市城关区人民医院, 甘肃 兰州 730030;
3. 新疆医科大学中医学院, 新疆 乌鲁木齐 830054
Author(s):
Zhang Jing12 Li Yingdong1 Gao Li3
1. Gansu College of TCM, 730000, Lanzhou, China;
2. The People’s Hospital in Chengguan District of Lanzhou, 730030, Lanzhou, China;
3. Xinjiang University of Medicine, 830054, Wulumuqi, China
关键词:
辛芷鼻敏胶囊变应性鼻炎EOSIL-5
Keywords:
Xinzhi Bimin Capsulesallergil rhinitisEOSIL-5
分类号:
R285.5
摘要:
目的:探讨辛芷鼻敏胶囊对变应性鼻炎(Allergic rhinitis,AR)实验性大鼠脾脏组织中白细胞介素-5(Interleukin-5,IL-5)和鼻黏膜嗜酸性粒细胞 (Eosinophil,EOS)表达的影响,明确其药效机制。方法:将40只大鼠随机分为4组,除正常对照组外,其余3组造模,造模成功后给药物治疗,7 d后测定各组IL-5含量,并计数EOS。结果:实验药物组的EOS计数和IL-5的含量明显低于模型对照组及阳性对照组(P<0.01或P<0.05)。结论:辛芷鼻敏胶囊能通过降低AR发病过程中IL-5的表达,减少EOS的浸润,从而控制AR症状。
Abstract:
Objective: To study the effects of Xinzhi Bimin Capsules on the contents of IL-5 in the spleen and the expression of EOS in the nasal mucosa of rats with allergil rhinitis(AR),and identify the mechanism of potency. Methods:40 rats were randomly divided into 4 groups.Except normal group,the rest were made models,and treated after successfully made models.The contents of IL-5 and the count of EOS was detected 7 days later. Results: The contents of IL-5 and the count of EOS in experimental group were significantly lower ones in model group and positive control group(P<0.01 or P<0.05). Conclusion: Xinzhi Bimin Capsules can control the symptom of AR by reduce the expression of IL-5 and the infiltration of EOS.

参考文献/References:

[1] Togias A. Rhinitis and asthma.:evidence for respiratory system integration[J].J Allergy Clin Immunol,2003,111:1171-1184.
[2] Mehle Me. Ara nasal steroids safe? Current opinion in otolaryngol[J]. Head and Neck Surgry, 2003,11:201-205.
[3] 黄选兆,汪吉宝.实用耳鼻咽喉科学[M].北京:人民卫生出版社,1998:255.
[4] 何芙莉.复方苍耳子滴鼻液治疗过敏性鼻炎实验观察[J]. 天津中医,1999,16(4):26.
[5] 中华医学会耳鼻咽喉科分会,中华耳鼻咽喉科杂志编委会. 变应性鼻炎诊断标准及疗效评定标准(1997年修订,海口)[J].中华耳鼻咽喉科杂志,1998,33(3):134.
[6] 陈永红,吕琳, 韦金育.穴位刺血对实验性鼻炎鼻分泌物的影响[J]. 辽宁中医杂志,1999,26:3.

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备注/Memo

备注/Memo:
收稿日期:2006-03-31;改回日期:2006-05-08。
作者简介:张静(1962-),女,副主任医师,在职硕士研究生,研究方向:外科疾病的中西医结合治疗。
更新日期/Last Update: 1900-01-01