[1]赵国磊,王兆坤,赵晨,等.风湿关节炎丸的质量控制方法研究[J].甘肃中医药大学学报,2014,31(06):32-35.
 Zhao Guolei,Wang Zhaokun,Zhao Chen,et al.Study on quality control standard of Fengshi Guanjieyan Pill[J].Journal of Gansu University of Chinese Medicine,2014,31(06):32-35.
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风湿关节炎丸的质量控制方法研究()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
31卷
期数:
2014年06期
页码:
32-35
栏目:
技术与方法
出版日期:
2014-12-25

文章信息/Info

Title:
Study on quality control standard of Fengshi Guanjieyan Pill
作者:
赵国磊1 王兆坤2 赵晨2 李凤丽3
1. 天津天士力制药股份有限公司, 天津 300410;
2. 天津中新药业集团股份有限公司达仁堂制药厂, 天津 300457;
3. 天津中医药大学第一附属医院, 天津 300193
Author(s):
Zhao Guolei1 Wang Zhaokun2 Zhao Chen2 Li Fengli3
1. Tianjin Tianshili Pharmaceutical Co. Ltd, Tianjin 300410, China;
2. Darentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co. Ltd, Tianjin 300457, China;
3. The First Affiliated Hospital of Tianjin University of TCM, Tianjin 3
关键词:
风湿关节炎丸薄层色谱法高效液相色谱法质量标准
Keywords:
Fengshi Guanjieyan PillTLC methodHPLC methodquality control standard
分类号:
R284.1
摘要:
目的 建立风湿关节炎丸的质量标准。方法 采用薄层色谱(TLC)法对风湿关节炎丸中的药材麻黄、当归、苍术进行薄层鉴别,采用高效液相色谱(HPLC)法对风湿关节炎丸中马钱子粉的有效成分士的宁进行含量测定。结果 薄层色谱专属性强,阴性对照无干扰;含量测定得士的宁的回归方程为Y=9.4223×105X+3.8175×104,r=0.9999,表明士的宁在15.6~234.0 μg/mL范围内呈良好的线性关系,平均回收率为98.80%,RSD为2.3%。结论 该方法简便快速,结果准确,可有效控制风湿关节炎丸的质量。
Abstract:
Objective To establish the quality standard of Fengshi Guanjieyan Pill. Methods Ephedrae Herba, Angelicae Sinensis Radix and Atractylodis Rhizoma were identified by TLC. As an active component of prepared strychni semen pulveratum, the content of strychnine was determined by HPLC.Results The specificity of identification was high and negative control showed no interference. The regression equation of strychine was Y=9.4223×105X+3.8175×104, r=0.9999. It showed a good linear relationship within 15.6~234.0 μg/mL. The average recovery was 98.80%. RSD was 2.3%. Conclusion The method is simple and accurate in controlling the quality of the pill effectively.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2014-02-10
作者简介:赵国磊(1978-),男,中级制药工程师,理学学士。研究方向:中药制剂工艺研究。
通信作者:李凤丽(1979-),女,主管中药师,在读博士研究生。研究方向:中药新药开发及有效成分的研究。E-mail:lfl992610@163.com
更新日期/Last Update: 1900-01-01