[1]万平新,高生晅,万芙蓉,等.理中活血汤联合幽门螺杆菌根除疗法治疗慢性萎缩性胃炎癌前病变46例临床观察[J].甘肃中医药大学学报,2016,33(04):44-47.[doi:10.16841/j.issn1003-8450.2016.04.13]
 WAN Pingxin,GAO Shengxuan,WAN Furong,et al.Clinical study on Lizhong Huoxue Tang combining Hp eradication therapy in treating chronic atrophic gastritis with precancerous lesions[J].Journal of Gansu University of Chinese Medicine,2016,33(04):44-47.[doi:10.16841/j.issn1003-8450.2016.04.13]
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理中活血汤联合幽门螺杆菌根除疗法治疗慢性萎缩性胃炎癌前病变46例临床观察()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
33卷
期数:
2016年04期
页码:
44-47
栏目:
临床研究与报道
出版日期:
2016-08-25

文章信息/Info

Title:
Clinical study on Lizhong Huoxue Tang combining Hp eradication therapy in treating chronic atrophic gastritis with precancerous lesions
作者:
万平新1 高生晅1 万芙蓉2 万顺梅3
1. 靖远县中医院康复科, 甘肃 靖远 730600;
2. 甘肃省康复中心医院体检科, 甘肃 兰州 730000;
3. 中国人民解放军第一医院消化科, 甘肃 兰州 730030
Author(s):
WAN Pingxin1 GAO Shengxuan1 WAN Furong2 WAN Shunmei3
1. Rehabilitation Department, Jingyuan TCM Hospital, Jingyuan, Gansu, 730600, China;
2. Medical Examination Department, Gansu Rehabilitation Center Hospital, Lanzhou, Gansu, 730000, China;
3. Gastroenterology Department, the First Hospital of PLA, Lanzhou, Gansu, 730030, China
关键词:
慢性萎缩性胃炎癌前病变理中活血汤Hp根除临床观察
Keywords:
chronic atrophic gastritisprecancerous lesionsLizhong Huoxue TangHp eradication therapyclinical observation
分类号:
R256.39
DOI:
10.16841/j.issn1003-8450.2016.04.13
摘要:
目的 观察理中活血汤联合幽门螺杆菌(Hp)根除疗法治疗慢性萎缩性胃炎(CAG)癌前病变的临床疗效。方法 将92例CAG癌前病变患者随机分为2组,对照组46例予Hp根除治疗,治疗组46例在对照组治疗方法的基础上给予理中活血汤治疗,2组疗程均为2周,观察2组的临床疗效、主要症候变化及病理疗效情况。结果 治疗组总有效率为84.78%,对照组为69.57%,2组比较差异有统计意义(P<0.05);治疗后2组主症积分、次症积分及总积分均显著降低,差异有统计意义(P<0.05),且治疗组治疗后降低更明显,差异有统计意义(P<0.05);治疗后治疗组胃黏膜萎缩、肠上皮化生、异型增生总有效率均高于对照组,且胃黏膜萎缩和肠上皮化生总有效率差异有统计意义(P<0.05);治疗组Hp根除率为91.30%,对照组为73.91%,2组比较差异有统计意义(P<0.05)。结论 理中活血汤联合Hp根除治疗不仅能改善CAG癌前病变患者的临床症状,而且对其癌前病变也有治疗作用。
Abstract:
Objective To observe the clinical efficacy of Lizhong Huoxue Tang (to regulate zhong-jiao and activate blood) combining Hp eradication therapy in treating chronic atrophic gastritis (CAG) with precancerous lesions. Methods 92 cases were randomized into control group and treatment group,46 cases in each. The control group was intervened with Hp eradication therapy. Based on that,the treatment group took Lizhong Huoxue Tang additionally,2 weeks as one course. Clinical efficacy,change of main symptoms and pathological effect were observed. Results The total effective rate was 84.78% in the treatment group and 69.57% in the control group with a difference (P<0.05). The symptom scores and the total scores of two groups were significantly decreased after treatment (P<0.05) and that of treatment group decreased more (P<0.05). The total effective rates of atrophic gastric mucosa,intestinal metaplasia and dysplasia in treatment group were much higher than in control group and there were significant differences in atrophic gastric mucosa and intestinal metaplasia between the two groups (P<0.05). The Hp eradication rates of treatment group and control group were 91.30% and 73.91% respectively,the difference was significant (P<0.05). Conclusion The therapy can improve the clinical symptoms of CAG with precancerous lesions,also is effective in treating precancerous lesions.

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备注/Memo

备注/Memo:
收稿日期:2015-10-08
作者简介:万平新(1976-),男,主治医师,医学学士,主要从事慢性萎缩性胃炎的中医临床研究。
通信作者:万顺梅(1965-),女,主任医师,医学博士,主要从事胃癌的临床与基础研究。E-mail:lily2008960@163.com
更新日期/Last Update: 1900-01-01