[1]张宏勇,赵继祖.中西医结合治疗早期糖尿病肾病30例临床观察[J].甘肃中医药大学学报,2016,33(05):37-39.[doi:10.16841/j.issn1003-8450.2016.05.11]
 ZHANG Hongyong,ZHAO Jizu.Clinical observation on 30 cases of early diabetic nephropathy treated with combined therapy of Chinese and Western medicine[J].Journal of Gansu University of Chinese Medicine,2016,33(05):37-39.[doi:10.16841/j.issn1003-8450.2016.05.11]
点击复制

中西医结合治疗早期糖尿病肾病30例临床观察()
分享到:

《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
33卷
期数:
2016年05期
页码:
37-39
栏目:
临床研究与报道
出版日期:
2016-10-25

文章信息/Info

Title:
Clinical observation on 30 cases of early diabetic nephropathy treated with combined therapy of Chinese and Western medicine
作者:
张宏勇 赵继祖
庆阳市西峰区人民医院内二科, 甘肃 庆阳 745000
Author(s):
ZHANG Hongyong ZHAO Jizu
The Second Internal Medicine Section, People’s Hospital of Qingyang City, Qingyang, Gansu, 745000, China
关键词:
糖尿病肾病补肾活血散缬沙坦分散片临床观察
Keywords:
diabetic nephropathy (DN)Bushen Huoxue SanValsartan Dispersible Tabletsclinical observation
分类号:
R4/78
DOI:
10.16841/j.issn1003-8450.2016.05.11
摘要:
目的 观察中西医结合治疗早期糖尿病肾病(DN)的临床疗效。方法 将60例早期DN患者随机分为2组。对照组30例采用西医常规治疗,包括饮食控制、体育运动、降糖和抗血小板治疗,并口服缬沙坦分散片;治疗组30例在对照组治疗方法的基础上加服补肾活血散。2组均以12周为1个疗程,1个疗程后比较2组的临床疗效,尿微量白蛋白排泄率(UAER)、尿β2-微球蛋白(β2-MG)水平。结果 治疗组总有效率为86.67%,对照组为63.33%,2组比较差异有统计意义(P<0.05);治疗后2组UAER与尿β2-MG均显著下降,与同组治疗前比较,差异均有高度统计意义(P<0.01),且治疗组下降程度更为显著,与对照组比较差异有统计意义(P<0.05)。结论 补肾活血散能够显著降低早期DN患者的UAER、尿β2-MG水平,从而保护肾脏功能,延缓早期DN的进展。
Abstract:
Objective To observe the efficacy of the combined therapy of Chinese and Western medicine in treating early diabetic nephropathy (DN). Methods 60 cases were randomly divided into control group and treatment group. The control group was intervened with conventional Western medicine therapy including diet control,physical exercise,blood sugar reducing and anti-platelet therapy as well as taking Valsartan Dispersible Tablets orally. The treatment group took Bushen Huoxue San additionally besides above mentioned therapy. 12 weeks was a period of treatment. The clinical efficacy,change of UAER and β2-MG were comparatively analyzed after one period. Results The total effective rates of treatment group and control group were 86.67% and 63.33% respectively,there was a significant difference (P<0.05). UAER and β2-MG of two groups decreased dramatically after treatment,the difference was significant (P<0.01). Compared with control group,the level of UAER and β2-MG decreased more in treatment group,also had a significant difference (P<0.05). Conclusion Bushen Huoxue San can reduce the level of UAER and β2-MG,thus protect the renal function and delay the progression of early DN patients.

参考文献/References:

[1] 陈灏珠,林果为.实用内科学[M].13版.北京:人民卫生出版社,2012:1054.
[2] 王海燕.肾脏病学[M].北京:人民卫生出版社,2009:1414.
[3] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010版)[J].中国糖尿病杂志,2012,20(1):1239-1240.
[4] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国中医药出版社,2002:165.
[5] 张锡纯.医学衷中参西录[M].石家庄:河北科技出版社,1997:60.
[6] 中国中医研究院.岳美中医案集[M].北京:人民卫生出版社,2005:31.

相似文献/References:

[1]赵固平,张兴旺,高小玲.尿微量蛋白检测在诊断糖尿病肾病早期损伤中的意义[J].甘肃中医药大学学报,2001,(04):26.
[2]马迎儿.加味猪苓汤结合常规疗法治疗糖尿病肾病30例临床观察[J].甘肃中医药大学学报,2017,34(01):42.[doi:10.16841/j.issn1003-8450.2017.01.13]
[3]张玉峰,黄积仓,杨国栋,等.生脉散合归脾汤加减治疗糖尿病肾病Ⅲ期气阴两虚型48例临床观察[J].甘肃中医药大学学报,2012,(06):33.
[4]徐玉娟.海昆肾喜胶囊治疗糖尿病肾病50例疗效观察[J].甘肃中医药大学学报,2012,(06):36.
[5]宋素华,王中甫,孟淑红.伊贝沙坦联合中药治疗糖尿病肾病疗效观察[J].甘肃中医药大学学报,2010,(06):37.
[6]马继国,蒋亚宝.川芎嗪、银杏达莫注射液配合西药治疗糖尿病肾病30例[J].甘肃中医药大学学报,2008,(03):29.
[7]杨小良,张春花.中医药综合治疗对糖尿病肾病患者生存质量的影响[J].甘肃中医药大学学报,2015,32(03):36.
 [J].Journal of Gansu University of Chinese Medicine,2015,32(05):36.
[8]王世彪,周孝德,王向东,等.补肾活血法治疗Ⅲ期糖尿病肾病35例临床观察[J].甘肃中医药大学学报,2002,(03):15.
[9]郭峰,刘锦.刺五加注射液与复方丹参注射液治疗糖尿病肾病微量蛋白尿之疗效对比[J].甘肃中医药大学学报,2002,(04):28.
[10]肖荣,郭兆安.中医药防治糖尿病肾病的机制研究进展[J].甘肃中医药大学学报,2013,(05):70.

备注/Memo

备注/Memo:
收稿日期:2015-11-03。
作者简介:张宏勇(1975-),男,主治医师,医学学士。研究方向:肾内科疾病的诊治。
更新日期/Last Update: 1900-01-01