[1]周丽琴.黄芪桂枝五物汤加减外用防治卡培他滨相关性手足综合征23例临床观察[J].甘肃中医药大学学报,2017,34(03):46-48.[doi:10.16841/j.issn1003-8450.2017.03.12]
 ZHOU Liqin.Clinical observation of the modified Huangqi Guizhi Wuwu Tang for external use in preventing and treating 23 cases with capecitabine related hand foot syndrome[J].Journal of Gansu University of Chinese Medicine,2017,34(03):46-48.[doi:10.16841/j.issn1003-8450.2017.03.12]
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黄芪桂枝五物汤加减外用防治卡培他滨相关性手足综合征23例临床观察()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
34卷
期数:
2017年03期
页码:
46-48
栏目:
临床研究与报道
出版日期:
2017-06-25

文章信息/Info

Title:
Clinical observation of the modified Huangqi Guizhi Wuwu Tang for external use in preventing and treating 23 cases with capecitabine related hand foot syndrome
作者:
周丽琴
浙江中医药大学第一临床医学院, 浙江 杭州 310053
Author(s):
ZHOU Liqin
The First Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, 310053, China
关键词:
手足综合征卡培他滨黄芪桂枝五物汤甲钴胺片临床观察
Keywords:
hand-foot syndromecapecitabineHuangqi Guizhi Wuwu Tangmecobalamin tabletsclinical observation
分类号:
R285.5
DOI:
10.16841/j.issn1003-8450.2017.03.12
摘要:
目的 观察黄芪桂枝五物汤加减外用防治卡培他滨相关性手足综合征(HFS)的临床疗效。方法 将46例接受卡培他滨化疗的乳腺癌、胃癌、大肠癌患者随机分为治疗组和对照组,各23例。对照组从化疗第1天开始口服甲钴胺片,0.5 mg/次,3次/d;治疗组从化疗第1天开始采用黄芪桂枝五物汤加减煎汤浸泡手足,2次/d,连泡21 d。2组均以21 d为1个疗程,6个疗程后比较2组患者的HFS发生率及严重程度。结果 治疗组HFS总发生率为52.2%,对照组为73.9%,2组比较差异无统计学意义(P>0.05);治疗组Ⅱ度及以上HFS发生率为13.0%,对照组为47.8%,差异有统计学意义(P<0.05)。结论 应用卡培他滨化疗时,预防性给予黄芪桂枝五物汤加减煎汤浸泡手足可以减轻卡培他滨致HFS的毒性,降低HFS发生的严重程度,改善肿瘤患者的生活质量,值得临床推广。
Abstract:
Objective To observe the curative effect of modified Huangqi Guizhi Wuwu Tang for external use in preventing and treating capecitabine related hand foot syndrome (HFS). Methods 46 malignant tumor patients,being under capecitabine chemotherapy,were randomly divided into treatment group and control group,23 cases for each. The patients in control group took mecobalamin tablets orally,0.5 mg each time,3 times a day;the patients in treatment group dipped their hands and feet into the Huangqi Guizhi Wuwu Tang,2 times a day for 21 days. 21 days were as one course for both groups. The incidences and severity of HFS in two groups were compared after six courses. Results The total incidences rates of HFS in the treatment group and control group were 52.2% and 73.9% respectively,the difference was not significant (P>0.05). However,the incidence rates of HFS on Ⅱ-level and above Ⅱ-level in treatment group and control group were 13.0% and 47.8% respectively,the diffe-rence was significant (P<0.05).Conclusion Preventive treatment of infusion by modified Huangqi Guizhi Wuwu Tang can reduce the toxicity and severity induced by capecitabine.The method can improve the life quality of tumor patients.It is worth popularizing and applying in clinic.

参考文献/References:

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相似文献/References:

[1]陈晓晓,黄挺.黄挺教授辨证论治化疗后手足综合征经验[J].甘肃中医药大学学报,2014,31(05):10.
 Chen Xiaoxiao,Huang Ting.Professor Huang Ting’s experience in the differential treatement of hand-foot syndrome after chemotherapy[J].Journal of Gansu University of Chinese Medicine,2014,31(03):10.

备注/Memo

备注/Memo:
收稿日期:2016-06-14。
作者简介:周丽琴(1990-),女,在读硕士研究生。研究方向:中西医结合治疗肿瘤疾病。
更新日期/Last Update: 1900-01-01