[1]李兵剑.乌梅丸保留灌肠治疗远端型溃疡性结肠炎24例临床观察[J].甘肃中医药大学学报,2018,35(02):53-57.[doi:10.16841/j.issn1003-8450.2018.02.15]
 LI Bingjian.Clinical observation of retention enema with Wumei Wan in treating 24 cases of distal ulcerative colitis[J].Journal of Gansu University of Chinese Medicine,2018,35(02):53-57.[doi:10.16841/j.issn1003-8450.2018.02.15]
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乌梅丸保留灌肠治疗远端型溃疡性结肠炎24例临床观察()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
35卷
期数:
2018年02期
页码:
53-57
栏目:
临床研究与报道
出版日期:
2018-04-25

文章信息/Info

Title:
Clinical observation of retention enema with Wumei Wan in treating 24 cases of distal ulcerative colitis
作者:
李兵剑
衡阳市中医医院肛肠科, 湖南 衡阳 421001
Author(s):
LI Bingjian
Anorectal Pepartment, Hengyang Hospital of TCM, Hengyang, Hunan, 421001, China
关键词:
溃疡性结肠炎远端型乌梅丸美沙拉嗪保留灌肠临床观察
Keywords:
ulcerative colitisdistal typeWumei Wanmesalazineretention enemaclinical observation
分类号:
R259.746.2
DOI:
10.16841/j.issn1003-8450.2018.02.15
摘要:
目的 观察乌梅丸保留灌肠治疗远端型溃疡性结肠炎(UC)的临床疗效。方法 将48例远端型UC患者采用随机数字表法分为治疗组和对照组,各24例。治疗组采用乌梅丸保留灌肠,对照组采用美沙拉嗪保留灌肠,100 mL/次,保留至少2 h,早、晚各1次。3周为1个疗程,1个疗程后比较2组的临床症状及内镜下表现评分、临床疗效、不良反应发生情况。结果 2组治疗后各临床症状、内镜下表现评分均较同组治疗前降低,差异均有统计学意义(P<0.05),且治疗组在黏液脓血便、里急后重、肛门灼热感、黏膜充血、黏膜水肿评分等方面降低更显著,差异均有统计学意义(P<0.05);治疗组总有效率为95.8%,对照组为91.7%,2组比较差异无统计学意义(P>0.05);对照组总不良反应发生率为25.1%,治疗组为4.2%,2组比较差异有统计学意义(P<0.05)。结论 乌梅丸保留灌肠治疗远端型UC疗效可靠,可显著降低临床症状、内镜下表现评分,且不良反应发生率低,值得临床推广应用。
Abstract:
Objective To observe the clinical effects of retention enema with Wumei Wan on treating distal ulcerative colitis(UC). Methods 48 patients with distal UC were divided into treatment group and control group by random number table method,24 cases in each. The treatment group were given Wumei Wan retention enema and the control group were given mesalazine retention enema,100 mL/time,and kept for 2 hours,once each morning and evening. 3 weeks was a course of treatment. After 1 course of treatment,the clinical symptoms and endoscopic performance scores,clinical efficacy,and adverse reactions of 2 groups were compared. Results The clinical symptoms and endoscopic performance scores of 2 groups after treatment were lower than those of the same group before treatment,the differences were statistical significance(P<0.05). The scores of mucous bloody stool,tenesmus,anal burning sensation,mucosal hyperemia and mucosal edema were significantly reduced in the treatment group,and the differences were statistical significance(P<0.05). The total effective rate was 95.8% in the treatment group and 91.7% in the control group,there was no significant difference(P>0.05). The total incidence rate of adverse reactions in the control group was 25.1%,and the treatment group was 4.2%,the difference was statistical significance(P<0.05). Conclusion The treatment of Wumei Wan was markedly effective for distal UC. It is worth popularizing and applying.

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备注/Memo

备注/Memo:
收稿日期:2017-06-13。
作者简介:李兵剑(1983-),男,主治医师,中医学硕士,主要从事肛肠疾病的临床防治与研究工作。
更新日期/Last Update: 1900-01-01