[1]陈晓婷,李林.自拟清化浊毒方联合质子泵抑制剂治疗难治性幽门螺杆菌感染慢性胃炎32例临床观察[J].甘肃中医药大学学报,2018,35(03):45-49.[doi:10.16841/j.issn1003-8450.2018.03.12]
 CHEN Xiaoting,LI Lin.Clinical observation on 32 cases of refractory h. pylori infection chronic gastritis treated by self-defined Qinghuazhuodu Prescritption combined with proton-pump inhibitor[J].Journal of Gansu University of Chinese Medicine,2018,35(03):45-49.[doi:10.16841/j.issn1003-8450.2018.03.12]
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自拟清化浊毒方联合质子泵抑制剂治疗难治性幽门螺杆菌感染慢性胃炎32例临床观察()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
35卷
期数:
2018年03期
页码:
45-49
栏目:
临床研究与报道
出版日期:
2018-06-25

文章信息/Info

Title:
Clinical observation on 32 cases of refractory h. pylori infection chronic gastritis treated by self-defined Qinghuazhuodu Prescritption combined with proton-pump inhibitor
作者:
陈晓婷1 李林2
1. 安徽中医药大学研究生院, 安徽 合肥 230000;
2. 安徽中医药大学第一附属医院干部脾胃科, 安徽 合肥 230000
Author(s):
CHEN Xiaoting1 LI Lin2
1. Postgraduate School, Anhui University of Chinese Medicine, Hefei, Anhui, 230000, China;
2. Splenico-Gastric Department, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230000, China
关键词:
慢性胃炎幽门螺杆菌清化浊毒方雷贝拉唑临床观察
Keywords:
chronic gastritishelicobacter pyloriHpQinghuazhuodu Prescriptionrabeprazoleclinical observation
分类号:
R259.733
DOI:
10.16841/j.issn1003-8450.2018.03.12
摘要:
目的 观察自拟清化浊毒方联合质子泵抑制剂(PPI)治疗难治性幽门螺杆菌(Hp)感染慢性胃炎的临床疗效。方法 将64例难治性Hp感染慢性胃炎患者采用随机数字表法分为对照组和治疗组,各32例。对照组采用四联疗法常规治疗,治疗组采用自拟清化浊毒方联合PPI治疗。连续治疗2周后比较2组的Hp根除率(停药1月后检测)、治疗前后的各中医症状积分及临床疗效。结果 对照组Hp根除率为43.8%,治疗组为53.1%,2组比较差异无统计学意义(P>0.05);治疗后2组各中医症状积分均明显下降,差异有统计学意义(P < 0.01),且治疗组的饱胀、嗳气、纳呆、恶心和嘈杂症状积分下降更显著,差异均有统计学意义(P < 0.05);对照组总有效率为59.4%,治疗组为87.5%,2组比较差异有统计学意义(P < 0.05)。结论 自拟清化浊毒方联合PPI治疗难治性Hp感染慢性胃炎临床疗效显著,可明显改善患者的胃肠功能,为治疗难治性Hp感染慢性胃炎提供了新思路。
Abstract:
Objective To observe the efficacy of self-defined Qinghuazhuodu (to clear away turbid) prescription combined with proton-pump inhibitor (PPI) in treating refractory h. pylori (Hp) infection chronic gastritis. Methods 64 cases of Hp infection chronic gastritis were randomly divided into control group and treatment group,32 cases in each. The control group was given conventional treatment,while the treatment group was intervened with self-defined Qinghuazhuodu Prescription combined with PPI. After 2-week treatment,Hp eradication rates,symptom scores and clinical efficacy of two groups were all compared. Results The eradication rate of control group was 43.8%,while that of treatment group was 53.1%,showing no any statistical significance (P>0.05). All symptom scores (distention,belching,anorexia,nausea,epigastric upset) decreased,while dropped more in treatment group,the difference was significant (P<0.05 or P<0.01). The total effective rate of treatment group and control group were 87.5% and 59.4% respectively,there was significant difference (P<0.05). Conclusion The combined therapy is effective in promoting patients’ gastrointestinal function,which also provide new ideas for the treatment of refractory h. pylori infection chronic gastritis.

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备注/Memo

备注/Memo:
收稿日期:2017-10-28。
作者简介:陈晓婷(1992-),女,在读硕士研究生。研究方向:中医内科脾胃病。
通信作者:李林(1962-),女,主任医师,医学学士,主要从事萎缩性胃炎、胆汁反流性胃炎及慢性腹泻的临床工作。E-mail:xiexie0192@163.com
更新日期/Last Update: 1900-01-01