[1]司小兵,陈淑彦,关东升,等.“咳喘宁”贴膏对支气管哮喘模型大鼠血清IL-8及TNF-α的影响[J].甘肃中医药大学学报,2006,(06):6-8,13.
 Si Xiaobing,Chen Shuyan,Guan Dongsheng,et al.The influence of Kechuanning Adhesive Plaster on IL-8 and TNF-α in serum of rats with bronchial asthma[J].Journal of Gansu University of Chinese Medicine,2006,(06):6-8,13.
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“咳喘宁”贴膏对支气管哮喘模型大鼠血清IL-8及TNF-α的影响()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
期数:
2006年06期
页码:
6-8,13
栏目:
实验研究
出版日期:
1900-01-01

文章信息/Info

Title:
The influence of Kechuanning Adhesive Plaster on IL-8 and TNF-α in serum of rats with bronchial asthma
作者:
司小兵 陈淑彦 关东升 王晶
甘肃中医学院, 甘肃 兰州 730000
Author(s):
Si Xiaobing Chen Shuyan Guan Dongsheng Wang Jing
Gansu College of Traditional Chinese Medicine, 730000, Lanzhou, China
关键词:
穴位贴敷"咳喘宁"贴膏支气管哮喘IL-8TNF-α
Keywords:
sticking to acupuncture pointsKechuanning Adhesive Plasterbronchial asthmaIL-8TNF-α
分类号:
R285.5
摘要:
目的:观察穴位贴敷"咳喘宁"贴膏对哮喘模型大鼠血清IL-8及TNF-α的影响。方法:将60只健康Wistar大鼠随机分为正常组、模型组、成药组、激素组、高剂量组、低剂量组6组,每组10只。卵白蛋白致敏并诱喘成功后,各治疗组分别予内服桂龙咳喘宁、地塞米松和穴位贴敷"咳喘宁"贴膏进行治疗。治疗6 d后,测定各组大鼠血清IL-8、TNF-α含量并比较其变化。结果:模型组大鼠血清IL-8、TNF-α水平较空白组明显升高(P<0.01);各治疗组IL-8、TNF-α水平较模型组显著降低(P<0.01或P<0.05);成药组和高、低剂量组IL-8、TNF-α水平降低不及激素组(P<0.01或P<0.05);高、低剂量组与成药组比较,均无显著性差异(P>0.05)。结论:穴位贴敷"咳喘宁"贴膏,能降低哮喘大鼠血清IL-8、TNF-α水平,减轻免疫炎性反应,其疗效虽不及内服地塞米松,但等同于内服桂龙咳喘宁,对哮喘有较好的防治作用。
Abstract:
Objective: To observe the influence of Kechuanning Adhesive Plaster sticked to acupuncture points on IL-8 and TNF-α in serum of rats with bronchial asthma. Methods: 60 Wistar rats in health were randomly divided into 6 groups:normal control group,model group,patent medicine group,hormone group,high-dose group and low-dose group. And each group had 10 rats.After sensitization by injecting ovalbumin and inducing asthma successfully,different preventive and curial treatments were given to them for 6 days.Then the content of IL-8 and TNF-α in serum were tested. Results: The contents of IL-8 and TNF-α in model group were significantly higher than those in normal control group(P<0.01).The contents of IL-8 and TNF-α in each treating group were lower than those in model group (P<0.01 or P<0.05). The contents of IL-8 and TNF-α in hormone group were lower than those in patent medicine group, high-dose group and low-dose group(P<0.01 or P<0.05). Conclusion: Kechuanning Adhesive Plaster can reduce the levels of IL-8 and TNF-α in serum by reducing the reaction of immune inflammation,it can prevent and treat asthma as well as Guilong Kechuanning.

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备注/Memo

备注/Memo:
收稿日期:2005-12-28
作者简介:司小兵(1980-),男,在读硕士研究生,主要从事免疫系统疾病的实验与临床研究。
更新日期/Last Update: 1900-01-01