[1]黄健飞,郭勇.自拟活血通络方泡洗防治紫杉醇所致周围神经毒性26例临床观察[J].甘肃中医药大学学报,2016,33(04):48-50.[doi:10.16841/j.issn1003-8450.2016.04.14]
 HUANG Jianfei,GUO Yong.Clinical observation on 26 cases of peripheral neurotoxicity induced by paclitaxel controlled by the immersion and wash therapy of Huoxue Tongluo Fang[J].Journal of Gansu University of Chinese Medicine,2016,33(04):48-50.[doi:10.16841/j.issn1003-8450.2016.04.14]
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自拟活血通络方泡洗防治紫杉醇所致周围神经毒性26例临床观察()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
33卷
期数:
2016年04期
页码:
48-50
栏目:
临床研究与报道
出版日期:
2016-08-25

文章信息/Info

Title:
Clinical observation on 26 cases of peripheral neurotoxicity induced by paclitaxel controlled by the immersion and wash therapy of Huoxue Tongluo Fang
作者:
黄健飞 郭勇
浙江中医药大学第一临床医学院, 浙江 杭州 310051
Author(s):
HUANG Jianfei GUO Yong
The First Clinical Medical College of Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, 310051, China
关键词:
紫杉醇周围神经毒性中药活血通络方泡洗临床观察
Keywords:
paclitaxelperipheral neurotoxicityChinese herbsHuoxue Tongluo Fangimmersion and wash therapyclinical observation
分类号:
R259
DOI:
10.16841/j.issn1003-8450.2016.04.14
摘要:
目的 观察自拟活血通络方泡洗防治紫杉醇所致周围神经毒性的临床疗效。方法 将51例接受含紫杉醇方案化疗的恶性肿瘤患者随机分为治疗组26例、对照组25例。对照组无预防性用药,出现外周神经毒性后予甲钴胺片口服,治疗组在对照组治疗方法的基础上,从首次化疗开始每日予自拟活血通络方泡洗,直至化疗结束。在完成紫杉醇药物全部疗程化疗后3周,比较2组患者的周围神经毒性发生率及严重程度。结果 治疗组周围神经毒性总发生率为61.5%,对照组为80.0%,2组比较差异无统计意义(P>0.05);治疗组Ⅱ级及以上级别周围神经毒性发生率为26.9%,对照组为56.0%,治疗组显著低于对照组,差异有统计意义(P<0.05)。结论 应用紫杉醇化疗时,预防性地给予中药活血通络方泡洗可减轻紫杉醇导致的周围神经毒性,降低周围神经毒性发生的严重程度,改善肿瘤患者的生活质量,值得临床推广。
Abstract:
Objective To observe the clinical efficacy of the immersion and wash therapy of Huoxue Tongluo Fang on controlling the peripheral neurotoxicity induced by paclitaxel.Methods 51 patients of malignant tumor were divided into treatment group with 26 cases and control group with 25 cases. The control group took mecobalamin tablets orally without any prophylactic treatment after occurring neurotoxicity. Based on that,the treatment group was intervened with self-made Huoxue Tongluo Fang by immersion and wash therapy from the beginning until the end of chemotherapy. On the 3rd week after treatment,the incidences and severity of the peripheral neurotoxicity in two groups were compared. Results The total incidence rates of peripheral neurotoxicity in the treatment group and control group were 61.5% and 80.0% respectively,the difference was not significant (P>0.05). However,the incidence rates of peripheral neurotoxicity on Ⅱ-level and above Ⅱ-level in the treatment group and control group were 26.9% and 56.0% respectively,the difference was significant (P<0.05). Conclusion Prophylactic treatment with Huoxue Tongluo Fang by immersing and washing can reduce the toxicity and severity induced by paclitaxel. The method can improve the life quality of tumor patients. It is worth popularizing and applying in clinic.

参考文献/References:

[1] 周际昌.实用肿瘤内科学[M].2版.北京:人民卫生出版社,2005:24.
[2] Kono T,Satomi M,Suno M,et al.Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation[J].Brain Behav,2012,2(1):68-73.

备注/Memo

备注/Memo:
收稿日期:2015-07-28
作者简介:黄健飞(1979-),男,副主任医师,在读博士研究生。研究方向:中西医结合肿瘤内科的临床研究。
通信作者:郭勇(1961-),男,主任医师,教授,医学硕士,主要从事中西医结合肿瘤内科的基础及临床研究。E-mail:doctorzjtcm@163.com
更新日期/Last Update: 1900-01-01