[1]贾沄.早期先兆流产合并绒毛膜下出血的中医证候分布规律及微观辨证指标的研究[J].甘肃中医药大学学报,2017,34(06):76-81.[doi:10.16841/j.issn1003-8450.2017.06.22]
 JIA Yun.Study on TCM syndrome distribution and microcosmic syndrome differentiation index of early threatened abortion with subchorionic hemorrhage[J].Journal of Gansu University of Chinese Medicine,2017,34(06):76-81.[doi:10.16841/j.issn1003-8450.2017.06.22]
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早期先兆流产合并绒毛膜下出血的中医证候分布规律及微观辨证指标的研究()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
34卷
期数:
2017年06期
页码:
76-81
栏目:
临床研究与报道
出版日期:
2017-12-25

文章信息/Info

Title:
Study on TCM syndrome distribution and microcosmic syndrome differentiation index of early threatened abortion with subchorionic hemorrhage
作者:
贾沄
广东省第二人民医院珠海医院(珠海高新技术产业开发区人民医院)中医科, 广东 珠海 519086
Author(s):
JIA Yun
Traditional Chinese Medicine Department, Zhuhai Hospital of the Second People’s Hospital in Guangdong Province, People’s Hospital in High and New Tech Development Zone of Zhuhai, Zhuhai, Guangdong, 519086, China
关键词:
早期先兆流产绒毛膜下出血中医证候γ-干扰素白介素-10孕酮雌二醇β-人绒毛膜促性腺激素相关性研究
Keywords:
early threatened abortionsubchorionic hematomaTCM syndromeINF-γIL-10progesteroneestraliolβ-HCGcorrelational study
分类号:
R714.21
DOI:
10.16841/j.issn1003-8450.2017.06.22
摘要:
目的 通过对早期先兆流产合并绒毛膜下出血的中医证候分布规律及中医证型与免疫-内分泌因素[Th1细胞因子γ-干扰素(INF-γ)、Th2细胞因子白介素-10(IL-10)、血清孕酮(P)、雌二醇(E2)、β-人绒毛膜促性腺激素(β-HCG)]相关性的研究,探讨早期先兆流产合并绒毛膜下出血的中医病机及微观辨证指标,为指导临床诊治及为本病的中医疗效评价提供参考。方法 证候分型构成及证型下的四诊指标的分析采用频数、频次及构成比描述性分析,对95例早期先兆流产合并绒毛膜下出血患者(观察组)的中医证候分布进行研究;对观察组及对照组的检测指标进行对比,总结、归纳观察组的中医证候分布规律及与微观辨证指标的相关性。结果 从中医证候分布情况来看,肾虚血热证最多见,之后依次为肾虚证、脾肾两虚证、气血虚弱证、肾虚血瘀证。微观指标组间比较,观察组血清INF-γ含量高于对照组,血清E2含量低于对照组,2组比较差异均有统计学意义(P<0.05),2组血清IL-10,P,β-HCG含量比较,差异均无统计学意义(P>0.05)。观察组各证型血清P,E2,β-HCG含量比较,差异均无统计学意义(P>0.05),肾虚血热证血清INF-γ含量与其他证型比较,差异有统计学意义(P<0.05),各证型血清IL-10含量比较,差异无统计学意义(P>0.05)。结论 早期先兆流产合并绒毛膜下出血的中医证候以肾虚血热证、肾虚证、脾肾两虚证最为常见;INF-γ,E2与早期先兆流产合并绒毛膜下出血有一定的相关性,可作为临床诊断的参考;肾虚血热证与早期先兆流产合并绒毛膜下出血的病因病机是否存在某种联系,还有待扩大样本量进一步研究。
Abstract:
Objective By the research on the correlation among TCM syndrome distribution rules,syndrome types and immune endocrine factors (Th1 cytokine INF-γ,Th2 cytokine IL-10,serum progesterone,estraliol and β-HCG) of early threatened abortion with subchorionic hemorrhage (SCH),the study is to explore the TCM pathogenesis of the case and microcosmic syndrome differentiation index,and to provide a reference for instructing the clinical diagnosis and treatment as well as evaluating the TCM curative effect.Methods Descriptive analysis of freuency,rate and constituent ratio was adopted to analyze the constitute and diagnostic indices of syndromes in 95 patients (observation group) of early threatened abortion with SCH.By comparison of the detection indexes of research group and control group,the correlation between TCM syndrome distribution rule and microcosmic index was summarized and concluded.Results As for the statistical distribution of TCM syndromes,the most common syndrome was kidney deficiency and blood heat,then followed by:kidney dificiency,deficiency of both spleen and kidney,deficiency of both qi and blood,kidney deficiency and blood stasis.In terms of comparison of microscopic indexes between the groups,INF-γ concentration of the observation group was higher than that of the control group,while estraliol concentration is lower than that of the control group,the differences were statistically significant (P<0.05),but the concentrations of IL-10,progesterone,β-HCG of two groups had no any significant difference (P>0.05).In observation group,there was no difference in comparing progesterone,estraliol,β-HCG (P>0.05).There was a difference in comparing INF-γ concentration in the patients of kidney deficiency and blood heat with other syndromes (P<0.05),while no difference existed in comparing IL-10 among all syndromes.Conclusion Kidney deficiency and blood heat,kidney dificiency,deficiency of both spleen and kidney are the common TCM syndromes of early threatened abortion with SCH.Correlation between estraliol and SCH can be used as a reference for clinical diagnosis.At the same time,it needs more samples to make further study on whether there is a link in kidney deficiency and blood heat with the etiology and pathogenesis of threatened abortion with SCH.

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备注/Memo

备注/Memo:
收稿日期:2017-02-06。
基金项目:广东省中医药局立项课题(20142024)。
作者简介:贾沄(1970-),女,主任医师,医学硕士,主要从事中医妇科临床、教学、科研工作。
更新日期/Last Update: 1900-01-01