[1]娄淑哲,李强.半夏泻心汤对胃溃疡大鼠胃黏膜病理形态及血管舒缩因子的影响[J].甘肃中医药大学学报,2018,35(06):12-15.[doi:10.16841/j.issn1003-8450.2018.06.03]
 LOU Shuzhe,LI Qiang.Effects of Banxia Xiexin Tang (半夏泻心汤) on gastric mucosa pathomorphology and vasomotor factors in gastric ulcer rats[J].Journal of Gansu University of Chinese Medicine,2018,35(06):12-15.[doi:10.16841/j.issn1003-8450.2018.06.03]
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半夏泻心汤对胃溃疡大鼠胃黏膜病理形态及血管舒缩因子的影响
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
35卷
期数:
2018年06期
页码:
12-15
栏目:
实验研究
出版日期:
2018-12-25

文章信息/Info

Title:
Effects of Banxia Xiexin Tang (半夏泻心汤) on gastric mucosa pathomorphology and vasomotor factors in gastric ulcer rats
作者:
娄淑哲1 李强2
1. 枣庄科技职业学院医学技术系, 山东 枣庄 277500;
2. 河北中医学院中医基础学院, 河北 石家庄 050091
Author(s):
LOU Shuzhe1 LI Qiang2
1. Department of Medical Technology, Zaozhuang Science and Technology Vocational College, Zaozhuang, Shandong, 277500, China;
2. Basic School of TCM, Hebei College of TCM, Shijiangzhuang, Hebei, 050091, China
关键词:
胃溃疡半夏泻心汤大鼠胃黏膜内皮素-1一氧化氮实验研究
Keywords:
gastric ulcerBanxia Xiexin Tang (半夏泻心汤)ratgastric mucosaET-1NOexperimental study
分类号:
R285.5
DOI:
10.16841/j.issn1003-8450.2018.06.03
摘要:
目的 观察半夏泻心汤对胃溃疡大鼠胃黏膜病理形态及血清内皮素-1(ET-1)、一氧化氮(NO)含量的影响。方法 从50只大鼠中随机抽取8只作为空白组,其余42只采用100%冰醋酸腐蚀法复制胃溃疡模型,造模成功后随机选取存活大鼠32只,随机分为模型组,奥美拉唑对照组,半夏泻心汤高、低剂量组4组,各组给予相应药物或生理盐水灌胃7 d,观察各组大鼠的胃黏膜病理形态,检测大鼠血清ET-1、NO的含量。结果 与模型组比较,各治疗组大鼠血清ET-1含量明显降低,NO含量明显升高,差异均有统计学意义(P<0.05或P<0.01);各治疗组大鼠血清ET-1含量比较,差异均无统计学意义(P>0.05);半夏泻心汤高剂量组大鼠血清NO含量明显高于半夏泻心汤低剂量组及奥美拉唑对照组,差异均有统计学意义(P<0.05)。半夏泻心汤能明显改善胃溃疡大鼠胃黏膜的病理形态。结论 半夏泻心汤可通过调节血管舒缩因子NO及ET-1的含量,从而达到保护胃黏膜、促进胃黏膜修复的目的。
Abstract:
Objective To observe the effects of Banxia Xiexin Tang (半夏泻心汤) on gastric mucosa path-omorphology and the content of serum ET-1 and NO in gastric ulcer rats. Methods Eight rats of the 50 ones were randomly chosen as the blank group, the rest 42 rats were used to establish the gastric ulcer model by glacial acetic acid corrosion. After successful modeling, 32 surviving rats were randomly chosen and divided into four groups:model group, omeprazole control group, Banxia Xiexin Tang high and low dose group, each group was given the corresponding medicine gavage or intragastric administration of normal saline for 7 days. We observed the gastric mucosa pathomorphology in rats of each group, and detected the content of serum ET-1 and NO in rats. Results Compared with the model group, the content of serum ET-1 decreased significantly while NO increased significantly in each treatment group, there were statistically significant differences among the groups (P<0.05 or P<0.01).There was no statistically significant differences in rats serum ET-1 among the groups (P>0.05);The content of rats serum NO in Banxia Xiexin Tang high dose group was significantly higher than that of Banxia Xiexin Tang low dose group and omeprazole control group, there were statistically significant differences (P<0.05). Banxia Xiexin Tang could significantly improve the gastric mucosa pathomorphology of gastric ulcer rats. Conclusion By regulating the content of serum NO and ET-1, Banxia Xiexin Tang can protect gastric mucosa and promote repair of gastric mucosa.

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备注/Memo

备注/Memo:
收稿日期:2018-06-15。
基金项目:河北中医学院青年科研基金资助项目(QNZ2014033)。
作者简介:娄淑哲(1984-),女,讲师,医学硕士,主要从事方剂学、中医护理学的教学工作及中医临床工作。
通信作者:李强(1982-),男,讲师,医学硕士。研究方向:中医内科。E-mail:yangmx427@163.com
更新日期/Last Update: 1900-01-01