[1]马奇翰,龚正丰,江国荣,等.吴门芪藤汤辅助治疗膝关节软骨损伤性关节炎20例临床观察[J].甘肃中医药大学学报,2018,35(06):57-61.[doi:10.16841/j.issn1003-8450.2018.06.12]
 MA Qihan,GONG Zhengfeng,JIANG Guorong,et al.Clinical observation on Wumen Qiteng Tang (吴门芪藤汤)in adjunctive treatment of 20 cases of traumatic arthritis of knee joint cartilage[J].Journal of Gansu University of Chinese Medicine,2018,35(06):57-61.[doi:10.16841/j.issn1003-8450.2018.06.12]
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吴门芪藤汤辅助治疗膝关节软骨损伤性关节炎20例临床观察
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
35卷
期数:
2018年06期
页码:
57-61
栏目:
临床研究与报道
出版日期:
2018-12-25

文章信息/Info

Title:
Clinical observation on Wumen Qiteng Tang (吴门芪藤汤)in adjunctive treatment of 20 cases of traumatic arthritis of knee joint cartilage
作者:
马奇翰1 龚正丰1 江国荣2 梁国强2 尤君怡1
1. 南京中医药大学附属苏州市中医医院骨伤科, 江苏 苏州 215003;
2. 南京中医药大学附属苏州市中医医院吴门医派研究院, 江苏 苏州 215003
Author(s):
MA Qihan1 GONG Zhengfeng1 JIANG Guorong2 LIANG Guoqiang2 YOU Junyi1
1. Department of Orthopedics and Traumatology, Suzhou Municipal Hospital of TCM Affiliated to Nanjing University of TCM, Suzhou, Jiangsu, 215003, China;
2. Institute of Wu Men School of Medicine, Suzhou Municipal Hospital of TCM Affiliated to Nanjing University of TCM, Suzhou, Jiangsu, 215003, China
关键词:
膝关节软骨损伤性关节炎吴门芪藤汤膝关节镜手术视觉模拟评分法评分膝关节功能评分白细胞介素-1肿瘤坏死因子-α基质金属蛋白酶-3临床疗效
Keywords:
traumatic arthritis of knee joint cartilageWumen Qiteng Tang (吴门芪藤汤)arthroscopic surgeryVAS scoreLysholm scoreIL-1TNF-αMMP-3clinical efficacy
分类号:
R274.943
DOI:
10.16841/j.issn1003-8450.2018.06.12
摘要:
目的 观察吴门芪藤汤辅助治疗膝关节软骨损伤性关节炎的临床疗效。方法 选择在本院经超声诊断为膝关节软骨损伤性关节炎的患者40例作为研究对象,根据病案号随机分为对照组和治疗组,各20例。对照组进行膝关节镜手术治疗,术后指导患者进行相应的功能锻炼及对症常规治疗;治疗组在对照组治疗方法的基础上给予吴门芪藤汤治疗,200 mL/次,2次/d。2周后比较2组的临床疗效,2组治疗前后的晨僵时间、视觉模拟评分法(VAS)评分及膝关节功能(Lysholm)评分,关节液中白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-3(MMP-3)含量。结果 治疗组总有效率为100%,对照组为90%,2组比较差异有统计学意义(P<0.05);治疗后2组晨僵时间明显缩短,VAS评分明显降低,Lysholm评分明显升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组对晨僵时间及Lysholm评分的改善作用更显著(P<0.05);治疗后2组关节液中的TNF-α、IL-1及MMP-3含量均明显降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组IL-1及MMP-3含量降低更显著(P<0.05)。结论 在膝关节镜手术基础上采用吴门芪藤汤治疗膝关节软骨损伤性关节炎,可以抑制患者关节积液中IL-1、MMP-3的过表达,改善患者膝关节功能,提高临床疗效,值得临床推广应用。
Abstract:
Objective To observe the clinical efficacy of Wumen Qiteng Tang (吴门芪藤汤) in adjunctive treatment of traumatic arthritis of knee joint cartilage. Methods Forty cases of traumatic arthritis of knee joint cartilage diagnosed by ultrasound in our hospital were chosen as research subjects, and they were randomly divided into control group and treatment group according to patients identification number, 20 cases in each one. The control group underwent knee arthroscopic surgery, and postoperative patients were instructed to perform corresponding functional exercises and symptomatic routine treatment;while the treatment group was given Wumen Qiteng Tang based on the treatment of control group, 200 mL per time, twice per day. The clinical efficacy of the two groups after two weeks of treatment, the morning stiffness time, VAS, Lysholm score, the content of IL-1, TNF-α and MMP-3 in joint fluid before and after treatment of the two groups were compared. Results The total effective rate of the treatment group was 100%, that of the control group was 90%, there was statistical significance between the two groups (P<0.05). The morning stiffness time significantly shortened, VAS score significantly decreased, Lysholm score significantly increased of the two groups after treatment, there was statistical significance compared with the same group before treatment (P<0.05), moreover, the improvement of morning stiffness time and Lysholm score in the treatment group was more significant (P<0.05). The content of TNF-α, IL-1, and MMP-3 in joint fluid all decreased in the two groups after treatment, there was statistical significance compared with the same group before treatment (P<0.05), moreover, the content of IL-1 and MMP-3 decreased more significantly in the treatment group (P<0.05).Conclusion Using Wumen Qiteng Tang on the basis of knee arthroscopic surgery to treat traumatic arthritis of knee joint cartilage can inhibit the excessive expression of IL-1 and MMP-3 in joint fluid of patients, improve the knee joint function of patients and clinical efficacy, which deserves clinical promotion and application.

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备注/Memo

备注/Memo:
收稿日期:2018-05-11。
基金项目:江苏省青年医学重点人才培养依托项目(QNRC2016252);江苏省苏州市级科技计划项目(SYSD2016194);江苏省苏州市产业技术创新项目(SYSD2017128)。
作者简介:马奇翰(1977-),男,副主任中医师,医学学士,主要从事脊柱和四肢骨折及骨关节炎等疾病的中西医联合治疗研究。
通信作者:尤君怡(1981-),男,副主任中医师,医学硕士,主要从事脊柱及四肢骨折的中医治疗和现代手术治疗,骨关节疾病及颈肩腰腿痛等疾病的中医治疗研究。
更新日期/Last Update: 1900-01-01