[1]姚鹏鹏,方居正.芪苈强心胶囊辅助治疗阳虚水泛型慢性心力衰竭36例临床观察[J].甘肃中医药大学学报,2020,37(01):76-80.[doi:10.16446/j.cnki.1001-1994.2020.01.017]
 YAO Pengpeng,FANG Juzheng.Clinical observation on Qili Qiangxin Jiaonang(芪苈强心胶囊) in adjuvant treatment of 36 cases of chronic heart failure with edema due to yang deficiency type[J].Journal of Gansu University of Chinese Medicine,2020,37(01):76-80.[doi:10.16446/j.cnki.1001-1994.2020.01.017]
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芪苈强心胶囊辅助治疗阳虚水泛型慢性心力衰竭36例临床观察
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
37卷
期数:
2020年01期
页码:
76-80
栏目:
临床研究与报道
出版日期:
2020-02-25

文章信息/Info

Title:
Clinical observation on Qili Qiangxin Jiaonang(芪苈强心胶囊) in adjuvant treatment of 36 cases of chronic heart failure with edema due to yang deficiency type
作者:
姚鹏鹏 方居正
平顶山市中医医院心血管内科, 河南 平顶山 467000
Author(s):
YAO Pengpeng FANG Juzheng
Department of Cardiovascular Diseases, Pingdingshan Municipal Hospital of TCM, Pingdingshan, Henan, 467000, China
关键词:
慢性心力衰竭阳虚水泛型芪苈强心胶囊阿托伐他汀片C反应蛋白N末端B型脑钠肽前体左心室射血分数左室舒张末期内径6 min步行距离临床观察
Keywords:
chronic heart failure(CHF)edema due to yang deficiency typeQili Qiangxin Jiaonang(芪苈强心胶囊)atorvastatin tabletsC-reactive protein(CRP)N-terminal brain natriuretic propeptide(NT-proBNP)left ventricular ejection fraction(LVEF)left ventricular end diast
分类号:
R259.416
DOI:
10.16446/j.cnki.1001-1994.2020.01.017
摘要:
目的 观察芪苈强心胶囊辅助治疗阳虚水泛型慢性心力衰竭(CHF)的临床疗效。方法 将72例阳虚水泛型CHF患者采用随机数字表法分为治疗组和对照组,各36例。2组根据患者病情酌情给予血管扩张剂、利尿剂、洋地黄制剂、血管紧张素转换酶抑制剂(ACEI)等常规治疗,对照组在常规治疗的基础上给予阿托伐他汀片治疗,治疗组在对照组治疗方法的基础上给予芪苈强心胶囊治疗。连续治疗8周后比较2组的临床疗效、治疗期间不良反应发生情况,治疗前后左室舒张末期内径(LVDD)、左心室射血分数(LVEF)、6 min步行距离及血清C反应蛋白(CRP)、N末端B型脑钠肽前体(NT-proBNP)的含量。结果 对照组总有效率为72.22%,治疗组为91.67%,2组比较差异有统计学意义(P < 0.05);2组治疗后LVDD及血清CRP、NT-proBNP含量均明显降低,LVEF及6 min步行距离均明显升高,与同组治疗前比较差异有统计学意义(P < 0.05或P < 0.01),且治疗组对各项指标的改善作用更明显,与对照组治疗后比较差异均有统计学意义(P < 0.05);2组在治疗期间均未发生明显不良反应。结论 芪苈强心胶囊辅助治疗阳虚水泛型CHF临床疗效显著,可有效改善患者的心功能,延缓心室重塑进展,提高运动耐力,且安全可靠,值得临床推广应用。
Abstract:
Objective To observe the clinical efficacy of Qili Qiangxin Jiaonang(芪苈强心胶囊) in adjuvant treatment of chronic heart failure(CHF) with edema due to yang deficiency type. Methods Seventy-two cases of CHF with edema due to yang deficiency type were divided into treatment group and control group according to random number table method,with 36 cases in each. The 2 groups was given routine treatment such as vasodilator,diuretic,digitalis preparation and converting enzyme inhibitor(ACEI) etc. according to the patient's condition,on this basis,the control group was given atorvastatin tablets,while the treatment group was given Qili Qiangxin Jiaonang based on the therapeutic method of the control group. After 8 consecutive weeks,the clinical efficacy,the incidence of adverse reactions during the treatment,left ventricular end diastolic diameter(LVDD),left ventricular ejection fraction(LVEF),6-minute walking distance and the serum levels of C-reactive protein(CRP) and N-terminal brain natriuretic propeptide (NT-proBNP) before and after treatment of the 2 groups were compared. Results The total effective rate of the control group was 72.22%,that of the treatment group was 91.67%,and the difference between the 2 groups was statistically significant(P<0.05). After treatment,LVDD and the serum levels of CRP and NT-proBNP all significantly decreased,while LVEF and 6-minute walking distance significantly increased,and the difference was statistically significant compared with the same group before treatment(P<0.05 or P<0.01),more- over,the improvement effect of treatment group was more significant,and the difference was statistically significant compared with the control group after treatment(P<0.05). No significant adverse reactions occurred in the 2 groups during the treatment.Conclusion It has marked clinical efficacy and reliable safety to use Qili Qiangxin Jiaonang in adjuvant treatment of CHF with edema due to yang deficiency type,which can effectively improve the heart function of patients,delay the progress of ventricular remodeling,and improve exercise endurance. It is worthy of clinical promotion and application.

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备注/Memo

备注/Memo:
收稿日期:2019-02-25。
作者简介:姚鹏鹏(1981-),男,主治医师,医学硕士。研究方向:中医内科心血管。
通信作者:方居正(1966-),男,主任医师,医学博士后。研究方向:中医内科心血管。E-mail:fangjuzheng6215@163.com
更新日期/Last Update: 1900-01-01